For the suppression of postpartum lactation, natural methods such as discontinuation of breastfeeding or mechanical compression of breast, or hormonal theraphy were used. But its effect was not so satisfactory. Then bromocryptine, a dopamine agonist, was used to suprresion of postpartum´ lactation and effect was good. But there was limitation 4 wide use of bromocryptine due to adverse effects, such as nausea, dizziness, postural ypotension and rebound lactation.
Lisuride, a semisynthetic dopamine agonist, also suprress postpartum lactation and has less side effect compared with bromocryptine.
A comparative study of effectiveness of lisuride with regard to dosage was carried o.it in 50 puperperal women.
1 The first group of 16 cases recieved 0.2mg of lisuride daily and 2nd group of 34 cases recieved 0.4mg of lisuride daily for 14days.
2 In frist group, milk secretion was found in 43.8% at first day, 56.3% at third day and breast congestion was found in 87.5% at first day, 68.8% at third day and there was no milk secretion or breast congestion at fifteenth days. However, in second group show milk secretion I´m 20.6% and 20.5% at first and third day each others, and breast congestion at 44.1% and 32.3% at first and third day and 2cases of breast congestion was found at 15th day.
3. Basal serum prolactin level was 110.752.4ng / me in first group and 102.594.4ng / mein second group and 46.429.0ng / me, 25.029.9 on each group at 15th day and the difference was statistically significant.
4. There was no significant untoward side effect on both group. After discontinuation of medication, rebound lactation was found at 62.5% in first group and 11.8% in second group. These rebound lactation was mild and disappeared in almost cases by further treatment of 7 days.
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